Endocrine Abstracts

Background: In acromegaly, carbohydrate metabolism disorders (CMD) are frequently observed. The effect of therapy of acromegaly on pathogenesis of CMD is not clear.Aim: To assess the effect of somatostatin analogues (SSA) on pathogenesis of carbohydrate metabolism disturbance in acromegaly.Patients and methods: 103 acromegaly patients were examined (31 men, 72 women; age 54 (46–61) years; 60 had newly diagnosed acromegaly (NA)...

Background: In acromegaly, carbohydrate metabolism disorders (CMD) are frequently observed. We aimed to assess the differences in insulin secretion and sensitivity depending on stage of the disease and type of treatment.Design: Sixty-four patients with acromegaly (46 women; age 53 (interquartile range, IQR 47–59) years), of whom 29 were newly-diagnosed (NA group), 20 treated with somatostatin analogues (SSA group) and 15 after transsphenoïdal s...

Introduction: Presence of thyroid peroxidase antibodies (TPOAbs) may be a marker of future thyroid failure. However, prospective studies in a euthyroid population have not been performed.Aim of the study: To prospectively investigate the relationship between presence and levels of TPOAbs and incident hypothyroidism in euthyroid subjects in the general population.Study population: The database used for this study consisted of a rand...

Background: The metabolic syndrome (MetS) is a combination of unfavourable health factors including abdominal obesity, dyslipidaemia, hypertension and impaired fasting glucose. Several small-scale studies have reported a relationship between thyroid function and some MetS components or suggested that serum FT3 levels within the normal range were independently associated with insulin resistance. We assessed how thyroid function relates to the prevalence of MetS in a large popul...

Background: Early diagnosis and treatment of high blood pressure (BP) and high cholesterol is important to reduce cardiovascular mortality risk.Methods: We assessed actual BP and LDL-cholesterol (LDL-C) levels in 88,029 participants (36,122 men), aged 18-80 yrs, without diabetes, from the Dutch Lifelines Cohort study. Participants were categorized according to degree of obesity (normal weight, overweight, obese) and age decade group. BP measurement was r...

Aim: We assessed in both men and women within different BMI- and age classes the prevalence of MetS and its individual components, since these specific estimates obtained simultaneously in a large western European population are lacking. Secondly, we measured as well how age-specific blood pressure (BP) cut-offs affect the prevalence of elevated BP and MetS.Methods: Data of 74 531 western European participants, aged 18–79 years, were obtained from t...

Background: Early carbohydrate metabolism disorders (ECMDs) and diabetes mellitus (DM) are frequently associated with endogenous hypercortisolism (EG). Prevalence of secondary (sDM) in these cases are poorly investigated.Aim: We aimed to assess the prevalence of ECMDs and DM in patients with EG (pituitary-dependent Cushing disease (CD)) and adrenal-dependent Cushing (AC) and ACTH-ectopic syndrome (ACTHs) depending on gender and age.<p class="abstext"...

Introduction: The metabolic syndrome (MetS) is a strong predictor of cardiovascular risk. It is influenced by environmental factors, and its prevalence is high in subjects with obesity.Design: We assessed differences in glucose- and lipid parameters, and hsCRP and microalbuminuria (MA) in obese subjects with and without metabolic syndrome (MetS) in LifeLines, a population-based study. Included were subjects 18–80 years, with BMI>30 kg/m2</s...

Introduction: Obesity is increasingly prevalent in Western society. In addition to medical consequences, obesity also affects health-related quality of life (HR-QOL).Design: We assessed the differences in HR-QOL in obese participants with and without metabolic syndrome (MetS), by level of obesity and level of inflammation, in the LifeLines Cohort study, a population-based study. In total, 12 765 subjects age 18–80 years, with BMI >30 kg/m2<...

Background: The clustering of metabolic and cardiovascular risk factors is known as the metabolic syndrome (MetS). Lifestyle factors like smoking may contribute to the differences in prevalence of the MetS. The aim of this study was to examine the association between smoking and the MetS and its components in different BMI classes.Methods: The present cross-sectional evaluation comprised 24 762 men and 35 558 women, participating in the LifeLines Cohort ...